Side Effects: Another Dose of Stories from a Count
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Azathioprine Imuran is also used to treat rheumatoid arthritis and as an antirejection medication for people who have had a kidney transplant. In myositis, it is usually taken orally by mouth , and is best taken with food to avoid stomach upset.
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Doses are usually started at 50mg twice daily, then increased by 50mg every two to four weeks. It may take up to six months for symptoms to improve.
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This medication also has an effect on the blood clotting mechanism in the body, so you may notice that you bruise more easily, and it may take longer for a wound to stop bleeding. Mycophenolate mofetil CellCept is also used to prevent rejection in organ transplant patients and to treat other autoimmune diseases. In myositis, it is usually taken orally by mouth at a dose of mg twice per day, increasing gradually to a dose of 2,,mg per day. Patients with kidney problems should use a lower dose. Mycophenolate mofetil has been used with good results in patients who have interstitial lung disease and in difficult to treat dermatomyositis skin disease, especially in combination with prednisone or other immunosuppressants.
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Cyclosporine is a natural product derived from a fungus. It is used to prevent rejection in organ transplant patients and to treat other autoimmune diseases. It is used as a second-line treatment in myositis, especially for patients who have interstitial lung disease ILD. Cyclosporine is taken orally, starting at 50mg twice a day and increase gradually to mg twice daily. Side effects include nausea, cough, fatigue, fever, high blood pressure, back pain, abdominal pain, and hair loss. It can also be toxic to the kidneys and nervous system.
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Tacrolimus Prograf is another drug that was developed as an antirejection medication for organ transplants. It works by inhibiting the production of interleukin-2 IL-2 , a molecule that promotes the development and proliferation of T cells in the immune system. Tacrolimus is taken orally at a dose of 1mg twice daily and increased slowly until optimal blood levels are achieved. Cyclophosphamide Cytoxan was developed as a chemotherapeutic agent to treat cancer.
It is also used as an antirejection medication for organ transplants. Because it can be fairly toxic, its use in myositis is limited to very refractory cases with interstitial lung disease ILD. By Clare Wilson. A patient-led movement is helping people taking psychiatric medicines to hack their dosing regimens so they can wean themselves off the drugs without any side effects.
Now a Dutch website that sells kits to help people do this is about to launch an English-language site, triggering safety concerns among UK regulators and doctors. Some people find it impossible to stop taking certain antidepressants and anti-anxiety medicines such as valium because, unless the dose is reduced very gradually, they get severe mental and physical side-effects.
People are hacking antidepressant doses to avoid withdrawal | New Scientist
This has prompted some people to flout mainstream medical advice and use DIY methods for reducing their doses, such as grinding up tablets and dissolving them in water, or breaking open capsules of tiny beads and counting them out. The UK mental health charity Mind advises people who want to stop taking antidepressants of some techniques to try, but recommends they get advice from their doctor or pharmacist first. The charity has been sending out such kits since , distributing around tapering kits for 24 different medications so far. Most of these were for people in the Netherlands, but a few kits have been sent to other countries, including the UK.
The website is in Dutch, but an English-language version is being launched next week.
Its actions are legal in the Netherlands, although most medical bodies advise people not to buy medicines over the internet. An increasing number of people are taking antidepressants — about 1 in 10 people in the UK, for instance.
Many people find antidepressants helpful, and even life-saving, but some struggle to stop taking them when they are ready. Some people say that when they try to stop, they experience intolerable side effects.
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A study in New Zealand found that 55 per cent of people got withdrawal symptoms on stopping antidepressants. He experienced dizziness, nausea and headaches when he stopped taking the antidepressant mirtazapine. Others who stop taking antidepressants report side effects such as panic attacks or memory and concentration problems.
Information leaflets that the drug manufacturers provide alongside the drug warn of short-term withdrawal effects, and doctors usually advise people to reduce their dose slowly. But even if people do that, once they stop taking the lowest dose of tablet available, some still get problems. Some people are told by their doctors that it is a relapse, even if it might not be.